Gut microbiota link with Alzheimer's Disease
New research from Lund University in Sweden have found that the microbiome of mice with Alzheimer's has a different composition to those without the disease.
Germ-free mice (completely lacking intestinal bacteria) given intestinal bacteria transfers from Alzheimer's mice, developed more beta-amyloid plaques (lumps that form at the nerve fibres of Alzheimer's sufferers) in the brain, compared to those with transfers from healthy mice. This shows a direct causal link and thanks to a grant from the EU, research can now progress to human trials to see if the effect is the same.
Harach, T, Marungruang, N, Duthilleul, N, Cheatham, V, Mc Coy, KD, Frisoni, G, Neher, JJ, Fåk, F, Jucker, M, Lasser, T & Bolmont, T 2017, 'Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota', Article, Scientific Reports, vol. 7, p. 41802.